abstract：:Prevention of nephrolithiasis (NL) is now medically feasible and widely recommended. However, diagnosis and treatment of remediable causes of stones requires testing and drugs that impose a cost; this cost is balanced by the presumed reductions in stone related events and medical encounters. In order to assess the bal...

journal_title：Kidney international

authors： Parks JH,Coe FL

更新日期：1996-11-01 00:00:00

abstract：:Cyclosporine A (CsA) is a potent immunosuppressive drug that inhibits the transcription of several proinflammatory cytokines including interleukin-2. In contrast, CsA stimulates transcription of the pleuripotent cytokine, transforming growth factor-beta (TGF beta). Since the effect of CsA in transplant recipients is u...

journal_title：Kidney international

authors： Pankewycz OG,Miao L,Isaacs R,Guan J,Pruett T,Haussmann G,Sturgill BC

更新日期：1996-11-01 00:00:00

abstract：:The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. We have shown that the interaction of VDRs with VDREs is inhibited by uremic toxins. We hypothesize that uremic toxins form Schiff bases with the lysine re...

journal_title：Kidney international

authors： Patel SR,Koenig RJ,Hsu CH

更新日期：1996-11-01 00:00:00

abstract：:The purpose of this prospective, angiographically controlled study was to determine the diagnostic value of color Doppler sonography with two differing approaches of scanning in patients with clinical clues for renal artery stenosis (RAS). In 135 hypertensive patients peak systolic velocity in the main renal arteries ...

journal_title：Kidney international

authors： Krumme B,Blum U,Schwertfeger E,Flügel P,Höllstin F,Schollmeyer P,Rump LC

更新日期：1996-10-01 00:00:00

abstract：:The initiation of peritonitis is accompanied by a massive increase in intraperitoneal levels of IL-6. The source of this cytokine and the mechanism by which its levels are increased so dramatically are unknown. We examined the mechanism of IL-6 secretion by HPMC exposed to the milicu present in the peritoneal cavity d...

journal_title：Kidney international

authors： Witowski J,Jörres A,Coles GA,Williams JD,Topley N

更新日期：1996-10-01 00:00:00

abstract：:Studies were conducted to investigate the impact of nitric oxide synthesis inhibition on blood pressure and glomerular hemodynamic adaptations to pregnancy in the rat. In normal pregnancy, urinary excretion of NO2 + NO3 (NOx), reflecting increased nitric oxide (NO) production, progressively increased. Blockade of NO p...

journal_title：Kidney international

authors： Deng A,Engels K,Baylis C

更新日期：1996-10-01 00:00:00

abstract：:Autologous and allogeneic bone marrow grafting both require cytoreductive therapy but only the allogeneic procedure requires immunosuppressive agents. Allogeneic bone marrow transplantation has been reported to be associated with a high incidence of both renal failure and veno-occlusive disease (VOD) of the liver, the...

journal_title：Kidney international

authors： Merouani A,Shpall EJ,Jones RB,Archer PG,Schrier RW

更新日期：1996-09-01 00:00:00

abstract：:Renal involvement in von Hippel-Lindau (VHL) disease has emerged as the most prevalent cause of death in this hereditary disorder. In a group of 43 VHL patients (23 unrelated families) with renal lesions we examined whether severity of renal disease is affected by parental inheritance and VHL subtype (1, without pheoc...

journal_title：Kidney international

authors： Chauveau D,Duvic C,Chrétien Y,Paraf F,Droz D,Melki P,Hélénon O,Richard S,Grünfeld JP

更新日期：1996-09-01 00:00:00

abstract：:The aging process in humans and in the rat is associated with an impairment in renal tubular reabsorption of Pi and renal tubular adaptation to a low Pi diet. The purposes of the present study were to determine whether changes in the abundance of type II Na-Pi contransporter (NaPi-2) protein and/or mRNA play a role in...

journal_title：Kidney international

authors： Sorribas V,Lötscher M,Loffing J,Biber J,Kaissling B,Murer H,Levi M

更新日期：1996-09-01 00:00:00

abstract：:Recent evidence suggests that glomerular hypertrophy is a key event in the development of focal and segmental glomerulosclerosis and hyalinosis (FSGS) in humans and in many experimental models of FSGS. The initial aim of the present study was to determine if glomerular hypertrophy occurs in a puromycin aminonucleoside...

journal_title：Kidney international

authors： Cahill MM,Ryan GB,Bertram JF

更新日期：1996-09-01 00:00:00

abstract：:Monocyte chemoattractant protein 1 (MCP-1) is a C-C chemokine with potent monocyte chemotactic and activating properties that may contribute to glomerular macrophage infiltration in anti-GBM Ab GN. We have previously reported increased glomerular steady state expression of MCP-1 mRNA relative to GAPDH mRNA in the hete...

journal_title：Kidney international

authors： Tang WW,Qi M,Warren JS

更新日期：1996-08-01 00:00:00

abstract：:We studied the specific binding of radiolabeled bradykinin ([3H]BK) and vasopressin ([3H]AVP) to membrane preparations of bovine and porcine kidney medulla. [3H]BK reversibly labeled a single site (Kd = 1.06 nM) in bovine kidney medulla independently of [Mg2+]. The number of BK receptors in bovine kidney medulla, Bmax...

journal_title：Kidney international

authors： Howl J,Yarwood NJ,Davies AR,Wheatley M

更新日期：1996-08-01 00:00:00

abstract：:The cytokine interleukin-6 (IL-6) is a major cell regulatory factor that may play an important role in the bone remodeling of patients with renal failure. IL-6 exerts its action by binding to its receptor (IL-6R), which leads to transduction of a second messenger cascade within cells. In vitro as well as in vivo data ...

journal_title：Kidney international

authors： Langub MC Jr,Koszewski NJ,Turner HV,Monier-Faugere MC,Geng Z,Malluche HH

更新日期：1996-08-01 00:00:00

abstract：:An effective therapeutic means to remove relatively large polypeptide uremic toxins seems to be a hemofiltration (HF) or hemodiafiltration (HDF) employing a larger-pore membrane, that is, a protein-permeable membrane. With either method, however, a significant amount of albumin will be lost into the ultrafiltrate or d...

journal_title：Kidney international

authors： Shinzato T,Miwa M,Nakai S,Takai I,Matsumoto Y,Morita H,Miyata T,Maeda K

更新日期：1996-08-01 00:00:00

abstract：:In summary, it is evident that malnutrition is highly prevalent in ESRD patients. This is clearly related to multiple factors encountered during the pre-dialysis stage, as well as during maintenance dialysis therapy. A body of evidence highlights the existence of relationship between malnutrition and outcome in this p...

journal_title：Kidney international

authors： Ikizler TA,Hakim RM

更新日期：1996-08-01 00:00:00

abstract：:Staphylococcal neutral phosphatase (NPtase) is a highly cationic bacterial surface bound protein. It has significant affinity for human and rat immunoglobulins in vitro and an electrostatic interaction may be involved. Radioisotopic studies showed that NPtase had a high affinity for the polyanionic structures of the r...

journal_title：Kidney international

authors： Yousif Y,Okada K,Batsford S,Vogt A

更新日期：1996-07-01 00:00:00

abstract：:Transepithelial fluid secretion promotes the progressive enlargement of cysts in autosomal dominant polycystic kidney disease (ADPKD). Recent indirect evidence indicated that active chloride transport may drive net fluid secretion in cultures of epithelia derived from ADPKD cysts. We now report that forskolin, which s...

journal_title：Kidney international

authors： Davidow CJ,Maser RL,Rome LA,Calvet JP,Grantham JJ

更新日期：1996-07-01 00:00:00

abstract：:In membranous nephropathy (MN) overproduction of matrix by glomerular epithelial cells (GEC) is believed to be responsible for glomerular basement membrane thickening and spikes. We studied experimental MN in rats (passive Heymann nephritis, PHN) at 5, 10 and 30 days. PHN rats exhibited a marked increase in GEC immuno...

journal_title：Kidney international

authors： Shankland SJ,Pippin J,Pichler RH,Gordon KL,Friedman S,Gold LI,Johnson RJ,Couser WG

更新日期：1996-07-01 00:00:00

abstract：:The formation of the non-sulphated glycosaminoglycan hyaluronan by cells of the renal glomerulus in diabetes may contribute to altered matrix composition. We describe an increased production of hyaluronan from mesangial cell-enriched glomerular cores from diabetic animals, and further show that increased hyaluronan pr...

journal_title：Kidney international

authors： Dunlop ME,Clark S,Mahadevan P,Muggli E,Larkins RG

更新日期：1996-07-01 00:00:00

abstract：:Substantial evidence implicates impaired renal excretion of sodium as the major culprit in the pathogenesis of hypertension. The key question is: How does the impairment of Na+ excretion lead to increased peripheral vascular resistance and elevation of the blood pressure? Here we describe the evidence that elevated le...

journal_title：Kidney international

authors： Blaustein MP

更新日期：1996-06-01 00:00:00

abstract：:Swelling activated anion channels have recently been recognized to play an important role in not only volume regulatory electrolyte movement, but also in organic osmolyte transport. A swelling-activated, outwardly rectifying anion channel termed VSOAC (volume-sensitive organic osmolyte/anion channel) is a major pathwa...

journal_title：Kidney international

authors： Jackson PS,Strange K

更新日期：1996-06-01 00:00:00

abstract：:The renal proximal tubule actively transports charged, potentially toxic xenobiotics from blood to lumen. Basolateral uptake of organic anions is indirectly coupled to the sodium gradient through Na-dicarboxylate cotransport and dicarboxylate-organic anion exchange. Upon entry, a significant fraction of intracellular ...

journal_title：Kidney international

authors： Pritchard JB,Miller DS

更新日期：1996-06-01 00:00:00

abstract：:We have sought to determine the mechanisms driving fluid secretion by the cystic epithelium in autosomal dominant polycystic kidney disease (ADPKD). We have performed in vitro experiments on intact cysts dissected from discarded ADPKD kidneys, on monolayers of cells cultured from the cystic epithelium and on microcyst...

journal_title：Kidney international

authors： Sullivan LP,Grantham JJ

更新日期：1996-06-01 00:00:00

abstract：:In his hypothesis of the evolution of renal functions Homer Smith proposed that the formation of glomerular nephron and body armor had been adequate for the appearance of primitive vertebrates in fresh water and that the adaptation of homoiotherms to terrestrial life was accompanied by the appearance of the loop of He...

journal_title：Kidney international

authors： Natochin YV

更新日期：1996-06-01 00:00:00

abstract：:To determine the prognosis and risk factors for ischemic heart disease in chronic uremia, a cohort of 432 dialysis patients were followed prospectively from start of dialysis therapy until death or renal transplantation. Baseline demographic, clinical and echocardiographic data were obtained. After the initiation of d...

journal_title：Kidney international

authors： Parfrey PS,Foley RN,Harnett JD,Kent GM,Murray D,Barre PE

更新日期：1996-05-01 00:00:00

abstract：:Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

journal_title：Kidney international

authors： Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

更新日期：1996-05-01 00:00:00

abstract：:Hemodynamic factors may play a role in the development of acute renal failure following administration of contrast media (CM). In this study the effect of intravenous injection of contrast media and mannitol on red blood cell velocity (VRBC) and red blood cell aggregation in renal medullary vessels was studied in 58 r...

journal_title：Kidney international

authors： Liss P,Nygren A,Olsson U,Ulfendahl HR,Erikson U

更新日期：1996-05-01 00:00:00

abstract：:The molecular mechanism of Na+ and phosphate transport by the intestinal brush border membrane Na+/phosphate cotransporter was examined using anion and cation exchange columns interfaced to a light-activated microsecond timer. The nature of ion:cotransporter interaction was examined for sensitivity to itself versus no...

journal_title：Kidney international

authors： Peerce BE

更新日期：1996-04-01 00:00:00

abstract：:The plasminogen activators (PA), which are regulated by their specific inhibitor, PAI-1, convert the zymogen plasminogen to plasmin, a protease involved in fibrinolysis and extracellular matrix turnover. Interleukin 1 beta (IL-1) is a key cytokine released from infiltrating monocytes/macrophages during the initial sta...

journal_title：Kidney international

authors： Wilson HM,Haites NE,Reid FJ,Booth NA

更新日期：1996-04-01 00:00:00

abstract：:The X-linked Hyp and Gy mutations are murine homologues of X-linked hypophosphatemia (XLH), a dominant disorder of phosphate (Pi) homeostasis characterized by growth retardation, rickets, hypophosphatemia and decreased renal tubular maximum for Pi reabsorption relative to glomerular filtration rate (Tmp/GFR). In Hyp a...

journal_title：Kidney international

authors： Tenenhouse HS,Beck L

更新日期：1996-04-01 00:00:00

abstract：:Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals. Cholesterol 7 alpha-hydroxylase (Ch-7 alpha-H) is the first and the rate limiting step in bile acid production. Recently, Ch-7 alpha-H enzymatic activity has been shown to be normal in r...

journal_title：Kidney international

authors： Liang KH,Oveisi F,Vaziri ND

更新日期：1996-03-01 00:00:00

abstract：:Long-term (5 years) treatment of 20 growth-retarded pre-pubertal children with chronic renal insufficiency (CRI) led to a significant (P < 0.00005) improvement in standardized height from -2.6 at baseline to -0.7 at five years. Eight patients were paused after reaching target height (50th centile midparental height) a...

journal_title：Kidney international

authors： Fine RN,Kohaut E,Brown D,Kuntze J,Attie KM

更新日期：1996-03-01 00:00:00

abstract：:We have previously shown that the activity of the Na-HCO3 cotransporter is stimulated by protein kinase C (PKC) activation, but the mechanism responsible for this effect is not clear. We have shown that cultured proximal tubule cells of the rabbit have DIDS-sensitive Na-HCO3 cotransporter activity as assessed by HCO3-...

journal_title：Kidney international

authors： Ruiz OS,Wang LJ,Qiu YY,Kear F,Bernardo A,Arruda JA

更新日期：1996-03-01 00:00:00

abstract：:The release of cytokines and prostaglandins (PG) by peritoneal macrophages (PM luminal diameter of) may influence the cytokine network controlling peritoneal inflammation and in the long-term the function of the peritoneum as a dialysis membrane. In the present study, an evaluation of the long-term effects of peritone...

journal_title：Kidney international

authors： McGregor SJ,Topley N,Jörres A,Speekenbrink AB,Gordon A,Gahl GM,Junor BJ,Briggs JD,Brock JH

更新日期：1996-02-01 00:00:00

abstract：:Protein and mRNA expression of TGF-beta isoforms, TGF-beta 1, -beta 2 and -beta 3, and deposition of fibronectin containing extra domain A (fibronectin EDA+) and plasminogen activator inhibitor-1 (PAI-1) were studied in human chronic glomerulonephritis and diabetic nephropathy. Normal kidneys showed similar, weak immu...

journal_title：Kidney international

authors： Yamamoto T,Noble NA,Cohen AH,Nast CC,Hishida A,Gold LI,Border WA

更新日期：1996-02-01 00:00:00

abstract：:We have recently presented evidence that endogenous nitric oxide (NO) and prostaglandins (PGs) modulate angiotensin II (Ang II) action in microperfused afferent arterioles (Af-Arts). Because flow may be a physiological stimulus of endothelial release of NO and PGs, we tested the hypothesis that flow through the lumen ...

journal_title：Kidney international

authors： Juncos LA,Ren Y,Arima S,Garvin J,Carretero OA,Ito S

更新日期：1996-02-01 00:00:00

abstract：:The inactivation of physiological glucocorticoids by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) confers mineralocorticoid specificity to certain aldosterone target tissues. Both NADP, and NAD-dependent isoforms of 11 beta-HSD have been described. An NAD-dependent isoform of 11 beta-HSD (11 beta-HSD2) was recen...

journal_title：Kidney international

authors： Kyossev Z,Walker PD,Reeves WB

更新日期：1996-01-01 00:00:00

abstract：:Nephropathia epidemica (NE) caused by Puumala hantavirus is one type of hemorrhagic fever with renal syndrome (HFRS). There is considerable variability in the clinical severity of NE. Many infections are subclinical but the disease can even be fatal. We questioned whether the wide spectrum in the outcome of NE is depe...

journal_title：Kidney international

authors： Mustonen J,Partanen J,Kanerva M,Pietilä K,Vapalahti O,Pasternack A,Vaheri A

更新日期：1996-01-01 00:00:00

abstract：:Hyperhomocysteinemia, an arteriosclerotic risk factor, persists in 75% of dialysis patients despite routine low dose supplementation with the B-vitamin co-factors/substrates for homocysteine (Hcy) metabolism, and normal or supernormal plasma status of these vitamins (Atherosclerosis 114:93, 1995). We conducted a place...

journal_title：Kidney international

authors： Bostom AG,Shemin D,Lapane KL,Hume AL,Yoburn D,Nadeau MR,Bendich A,Selhub J,Rosenberg IH

更新日期：1996-01-01 00:00:00

abstract：:Colony stimulating factor-1 (CSF-1) is a chemoattractant and growth factor for macrophages. In autoimmune MRL-lpr mice, CSF-1 is detected in the circulation and there is an increase in CSF-1 transcripts and macrophages in the kidney. The purpose of this study was to establish whether the MRL-lpr kidney is responsible ...

journal_title：Kidney international

authors： Naito T,Griffiths RC,Coffman TM,Kelley VR

更新日期：1996-01-01 00:00:00